Sentence examples for membrane potential directly from inspiring English sources

Membrane potential directly applies an electrostatic force on any electric charge (e.g. a proton bound to a titratable residue) in a membrane protein.

As the membrane potential directly regulates the open probability of NMDA receptors and voltage-gated calcium channels, the morphological and electrophysiological properties of the dendrite are closely related to the intracellular calcium concentration, and may also affect the regional specificity of LTD induction and the generation of the long-lasting synaptic reduction.

Considering that mitochondrial membrane potential directly affects mitochondrial activity, we monitored this parameter in our experimental paradigm.

The intrinsic pathway is initiated through either the disruption of the mitochondrial membrane potential directly or indirectly through upstream effector molecules.

The effects of the two pathways on membrane potential are also likely to differ: opening of IP3R within the PM is likely to cause depolarization, whereas Orai channels are exquisitely Ca2+-selective and unlikely to regulate membrane potential directly.

Resting membrane potential was directly measured in current-clamp mode after membrane rupture and only cells with a resting membrane potential more negative than −50 mV were studied.

This pathway eliminates mitochondria in mammalian erythrocytes by disrupting mitochondrial membrane potential and directly recruiting microtubule-associated protein 1 light chain 3 beta homologs to the mitochondria via an LC3-interacting region motif (Sandoval et al. 2008; Zhang and Ney 2009; Kanki 2010; Novak et al. 2010; Birgisdottir et al. 2013).

This effect is not unexpected because the membrane potential does not directly enter the cost function in the parameter estimation procedure.

This was interpreted as evidence that the RyR might sense membrane potential (182) either directly (because it was resident within the PM) (175, 178) or indirectly via conformational coupling to another PM voltage sensor.

The peculiar arrangement of sulfhydryl groups within the membrane could also alter the redox potential of the membrane or potentially directly chelate metal ions.

Moreover loss of PINK1 function results in increased levels of oxidative stress and reduced mitochondrial membrane potential, suggesting that mitochondrial dysfunction directly leads to the increased susceptibility to apoptosis.