Sentence examples for mediators that include from inspiring English sources

IGF-I signalling is mediated by a network of intracellular mediators that include the phosphatidylinositol-3-kinase/Akt pathway and the mitogen-activated kinase cascades.

This imbalanced reaction may harm the host through a maladaptitive release of endogenous mediators that include cytokines and nitric oxide.

Cyclooxygenase (COX) enzymes catalyze the two-step conversion of arachidonic acid to the unstable prostaglandin (PG) intermediate PGH2, which is then further converted to a range of prostanoid mediators that include PGE2, prostacyclin (PGI2) and thromboxane (TXA2).

Chronic synovitis is a source of inflammatory mediators that include cytokines, chemokines and adipokines, such as TNF-α, macrophage chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1, interleukin (IL -6 and others.

In the present study we plan to analyze a panel of immune/inflammatory mediators that include: pro-inflammatory cytokines (IL-1, IL-6, TNF-α, IL-17, IFN-γ), anti-inflammatory cytokines (IL-10 and TGF-β); soluble endothelial adhesion molecules (E-Selectin, ICAM-1 and VCAM-1) and Th1, Th17 and Treg lymphocytes.

FcγRs bind to Ig and to the pentraxin family of immune mediators that includes C-reactive protein and serum amyloid P (SAP).

Prostaglandin E2 (PGE2), the most abundant PG in humans, is another inflammatory mediator with widespread effects that include regulation of blood vessels (Norel, 2007).

Treg are known to limit the inflammatory reactions using several mechanisms that include soluble mediators, cell-to-cell contact with Teff or inhibiting antigen presenting cells (APCs) [ 1].

It specifically hydrolyzes phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.

Future studies should develop complex conceptual and statistical models that include moderators and mediators, improve objective and perceived measures of the built environment, and strengthen evidence of causality through better research designs.

The inflammatory mediator PGE2 exerts a range of biological activities that include stimulation of inflammation-associated bone resorption (5).