Sentence examples for mediators that contribute from inspiring English sources

The microglia have been observed to release various inflammatory mediators that contribute to the long-term occurrence of inflammation in the HD brain, resulting in damage and cell death.

We hypothesized that some of the mediators that contribute to the inflammation process in the joint may serve as informative biomarkers to discriminate between patients with post-traumatic osteoarthritis and healthy subjects, especially patients with early-grade OA.

There is considerable amount of data on pro-inflammatory mediators that contribute to the development of allergic inflammation.

Psoriatic keratinocytes show abnormal differentiation and proliferation, have aberrant cell signaling and produce mediators that contribute to the recruitment and activation of immune cells [11].

However, knowledge of the mediators that contribute to chemoresistance is pivotal to the identification of high-risk patients and the development of new therapeutic strategies.

Such immunoregulatory role is due to the IL-10 ability of inhibiting the expression of the most inducible cytokines and secondary mediators that contribute to inflammation.

This can be through a downregulation on the synthesis of proinflammatory mediators that contributes to restoring homeostasis of the septic patients.

And some groups identified FSTL1 as a new proinflammatory mediator that contributes to rheumatoid arthritis by promoting the expression of TNFα, IL-1β, IL-6 and IL-8, as well as by enhancing the interferon-γ (IFN-γ) signaling pathway in a mouse model [ 22, 31, 32].

Cyclic AMP is a key intracellular mediator that contributes to bronchoconstriction in asthmatic airways.

COX-2-derived PGE2 has emerged as a tumor-derived mediator that contributes to development of immune tolerance [ 11- 13].

So what are the exact mediators of interferon that contribute to its beneficial effects in Sandler and colleagues' study?