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It has been shown before that inflammatory mediators can affect lipid metabolism (reviewed by Khovidhunkit et al. [27]).
However, two groups recently published that chronic inflammation can potentiate this process in the brain, muscle, liver and heart [11], [12] suggesting that physiologic mediators can affect cell fusion.
Besides direct effects on the joint, inflammatory mediators can affect muscle function and sensitize nerves leading to increased pain [ 13].
Inflammation also plays a critical role in MCL injury and repair after injury [ 29, 30], and upregulation of inflammatory mediators can affect muscle function.
Proinflammatory stimuli, including hyperglycemia, oxidative stress, and other inflammatory mediators, can affect epigenetic mechanisms, altering the expression of specific genes in target cells without changes in underlying DNA sequences.
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These unique allergic and immunological responses cause the release of mast cell mediators that can affect the central nervous system resulting in detrimental behavioral effects in certain children with autism [ 59].
By drawing a distinction between the incentive landscape and the planning process, we identify process as a mediator that can affect organizational outcomes.
A number of released mediators can also affect the producing cell itself.
Oxidative stress can promote the formation/release of a variety of vasoactive mediators [ 36] that can affect renal function directly by causing renal vasoconstriction or decreasing the glomerular capillary ultrafiltration coefficient, thus reducing the GFR.
Since the salivary transcriptome was clearly altered in tumor-bearing vs. control mice, we hypothesized that the tumors behave like endocrine organs in that they secrete mediators (hormones, lymphokines, cytokines) which can affect the activity of TF in salivary glands and thereby induce up or down-regulation of transcripts levels in saliva.
Turning to the setting with two mediators we first note that can affect but not vice versa; in some applications, there may be doubt as to the direction of the arrow between and, which would introduce further difficulties beyond the scope of this article.
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