Sentence examples for mediators can lead from inspiring English sources
The aberrant production of proinflammatory mediators can lead to multiorgan failure and even death.
Reduced venous return, endotoxic shock and release of inflammatory mediators can lead to cardiovascular impairment and rapid death [ 17].
These factors and mediators can lead to endothelial dysfunction, which underlies the clinical manifestations of preeclampsia (Baumwell and Karumanchi 2007; Wang et al. 2009).
SIRS refers to the systematic inflammatory response leading to a massive, uncontrollable release of inflammatory factors [ 2]. High levels of inflammatory mediators can lead to the increase of blood capillary permeability and pulmonary edema, resulting in acute respiratory distress syndrome, multiple organ failure, high mortality and other clinical disorders requiring hospitalization.
Undergoing systemic inflammation, the innate immune system releases excessive proinflammatory mediators, which finally can lead to organ failure.
However, combined approaches that reduce TNF load and block IL-1 or RANKL as downstream mediators of TNF can lead to a complete remission.
Actions of such key pathological mediators of diabetes can lead to dysregulated epigenetic mechanisms that affect chromatin structure and gene expression profiles [ 12].
Although these molecules are crucial for host defense against invading bacteria, excessive production of these mediators can result in a lethal systemic inflammatory response syndrome, which leads to shock, vascular dysfunction, disseminated intravascular coagulation and multiple organ dysfunction/injury [ 3].
The sustained presence of inflammatory mediators in the vasculature can lead to vessel wall endothelial activation.
The release of vasoactive mediators into the circulation can lead to vascular collapse and anaphylactic shock.
TNF-α and IL-6 act through classical receptor-mediated processes, resulting in upregulation of potential mediators of systemic inflammation that can lead to insulin resistance.
