Sentence examples for mediator of downstream from inspiring English sources

We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology.

The known functions of some of its members, for example AP1, the module's central location in the inferred network, and its preferential targeting by pathogens suggest that it may be an early mediator of downstream functions, possibly as a checkpoint of progression to apoptosis or inflammation.

These observations are consistent with our conclusion that in macrophages, LynA is the primary mediator of downstream signaling in response to 3-IB-PP1.

Thus, our results clearly demonstrate that LTB4 can act via its receptors BLT1 and BLT2 to significantly activate the phosphorylated form of PLA2, which is an important mediator of downstream LTB4 production.

The key contribution of the series of Drosophila p53 papers from the Helfand laboratory is the placement of p53 as a key mediator of downstream CR signaling effects, in part through its effects on insulin signaling pathways.

Through a stretch of four C-terminal amino acids, trans-interacting nectins recruit afadin, a scaffold-like mediator of downstream signaling, triggering assembly of the afadin/Rap1/p120ctn complex, which positively regulates membrane retention of E-cadherin, assisting in adherens junction (AJ) formation in MDCK cells (Hoshino et al., 2005).

Other aspects of EGFR family signaling, including other types of EGFR mutations, EGFR protein expression, EGFR gene amplification, mediators of downstream signaling, and other receptors with similar downstream pathways may all play a role in response or resistance to treatment.

Importantly, in many of these cases, OP-1 modulated the expression of not only the ligands, but also their receptors, mediators of downstream signaling, kinases responsible for an activation of the pathways and transcription factors that induce transcriptional responses.

In many of these cases, OP-1 modulated the expression of not only the ligands, but also their receptors, mediators of downstream signaling, kinases responsible for an activation of the pathways, binding proteins responsible for the inhibition of the pathways, and transcription factors that induce transcriptional responses.

Focal adhesion kinase (FAK) is also a major mediator of signals downstream of integrins [49], [50] and is known to signal through Grb2 [55], [55].

As in 'classical' senescence, p21 CDKN1A) is a major mediator of these downstream effects.