The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown.
We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology.
Interest in TG2 as mediator of HD pathophysiology has garnered increasing support via observations from several labs (all working in diverse models of HD that range from cells to non-human primates), that cystamine, a low molecular weight inhibitor of TG2, is neuroprotective (Karpuj et al, 2002; Fox et al, 2004).
Introduction: Extracellular microvesicles (MVs) are subcellular plasma membrane-enclosed particles released from activated and apoptotic cells, emerging as key indicators and mediators of disease pathophysiology.
All the above discussed mediators of sepsis pathophysiology might be exploited to gain useful data on the prognosis and early diagnosis of systemic inflammatory response syndrome (SIRS) patients.
We suggest that the metabolic and electrolytes changes induced by PTH rather than renal failure itself are the major mediators of AVC pathophysiology.
As presented in other reviews in this supplement [ 12, 13], transforming growth factor-β appears to be an important mediator of much of the pathophysiology of SSc, particularly in terms of extracellular matrix deposition and vasculature injury.
Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA).
Future studies will dissect the functional significance of different metabolic pathways in the production of toxic lipid mediators of sugar-induced pathophysiology.
