Apaf-1, a critical scaffolding protein required for cytochrome c-mediated caspase activation, is an essential mediator of cell death by apoptosis.
This gene is a potential mediator of cell death that cooperates to the p53-mediated cell death pathway.
Bcl2-interacting mediator of cell death.
Knocking down NOR-1 suppressed DNA synthesis in SMCs, suggesting that NOR-1 is a mediator of cell elongation effects.
Adrenomedullin (ADM) is a 52-amino acids peptide, and a marker of the CALC gene family, acting as a mediator of cell proliferation, hormone regulation and embryogenesis.
Although no single factor has been identified as the critical mediator of cell death, depletion of cellular energy stores plays a major role [10].
We further showed that such inhibition leads to inhibition of proliferation and up-regulated expression of the apoptotic regulator Bcl-2-interacting mediator of cell death (Bim).
p19ARF oncosuppressor is known as a key mediator of cell senescence.
This is consistent with intramitochondrial Fe2+ being the chief mediator of cell death most likely via the Fenton reaction.
However, strikingly, dinJ-yafQ seems to be a principal mediator of cell death in biofilm formation (Figures 3 and 4).
relBE seems to be a principal mediator of cell death only in liquid media (Figure 2, [30]), but not in biofilm formation (Figure 3).
