Sentence examples for mediating tissue damage from inspiring English sources

Although multiple pathways are involved in mediating tissue damage, including the polyol pathway, advanced glycation end product formation, protein kinase C activation, and the hexosamine pathway, a common feature is increased oxidative stress marked by elevated levels of reactive oxygen species (ROS) (1).

In line with these findings, a recent report demonstrated that CD4+ Tems can damage endothelial cells and it was found that this process was independent of the CD28 costimulatory pathway, supporting a role for CD4+CD28null Tems in mediating tissue damage [ 64].

Phagocyte generated free radicals have been implicated in mediating tissue damage associated with various inflammatory vasculopathies.

This process is important in the homeostasis of the inflammatory response, and delayed neutrophil apoptosis has been implicated in mediating tissue damage in acute respiratory distress syndrome and systemic inflammatory response syndrome [ 14- 16].

The evidence from these studies (discussed below) suggests that NK cells can affect the development of autoimmunity through several mechanisms, including suppressing viral infections and potential subsequent autoimmune responses, modulating autoreactive responses of other immune cells, or, as effector cells, directly mediating tissue damage (Fig. 2).

ROS generation during ischemia is a consequence of ischemia mediated tissue damage [20] [22].

All together these studies signify that ischemia induced ROS generation by cellular systems plays a major role in ischemia mediated tissue damage.

Several studies have suggested that often it requires more than a single cytokine to influence the cell mediated tissue damage in response to microbial infection and a fine-tuning of multiple cytokines is de rigueur for an effective clearance of the pathogen [39], [40].

However, NK cells also appear to mediate tissue damage during the acute phase of sepsis.

Oxidative stress mediated tissue damage also increases the liver marker enzyme activities.

The CP has not been shown to be a major pathway for complement mediated tissue damage in MRL/lpr mice.