Sentence examples for mediate tissue damage from inspiring English sources

However, NK cells also appear to mediate tissue damage during the acute phase of sepsis.

54 Neutrophils mediate tissue damage by cytotoxic and proinflammatory cytokine production and can infiltrate the organ within hours after surgical trauma or ischemia has been established.

Moreover, immune-mediated liver injury is a consequence of the recruitment of effector leukocytes to the liver where they mediate tissue damage.

TRAIL is upregulated on SLE T cells [ 45, 46] and in lupus serum [ 47], and has been proposed to mediate tissue damage [ 46] and nephritis [ 48].

ANCA targeting primary granule antigens expressed on the neutrophils are known to elicit neutrophil activation and degranulation and subsequently mediate tissue damage [ 24– 26].

As resident brain macrophages, microglia function as sentries, but when activated they can mediate tissue damage, a scenario considered for several CNS inflammatory disorders (10, 15, 27).

The migratory properties of peripheral blood-borne monocytes and their ability to enter the central nervous system, suggests a beneficial role in mediating tissue damage and neuroinflammation.

However, prolonged inflammation is detrimental and mediates tissue damage and is considered a major pathogenic factor for the development of chronic non-healing wounds and may be a trigger for auto-inflammatory skin diseases such as psoriasis.

ROS generation during ischemia is a consequence of ischemia mediated tissue damage [20] [22].

All together these studies signify that ischemia induced ROS generation by cellular systems plays a major role in ischemia mediated tissue damage.

Several studies have suggested that often it requires more than a single cytokine to influence the cell mediated tissue damage in response to microbial infection and a fine-tuning of multiple cytokines is de rigueur for an effective clearance of the pathogen [39], [40].