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Exact(5)
IAPs were described critical in mediating host cell viability.
The glycoproteins present on these viruses are responsible for mediating host cell attachment and fusion and are key targets for the design of antiviral entry inhibitors.
These results indicate that C. parvum EF-1α plays an essential role in mediating host cell entry by the parasite and, as such, could be a candidate vaccine antigen against cryptosporidiosis [ 23].
One possibility is that there is a small amount of GM1 in the cells, which is capable of mediating host cell intoxication via pathway that operates in parallel to the fucosylated glycoproteins.
One possibility is that the cells contain a level of GM1 that is not detectable by the sensitive methods employed in Figure 3, but which is nonetheless capable of mediating host cell intoxication via a pathway that operates either in parallel or in concert with that mediated by fucosylated glycoproteins.
Similar(55)
In short, the DV E protein mediates host cell binding and is essential for infection via a conformation-induced membrane fusion event between the host cell and the virion.
The adherence mediates host cell signaling events and elicits a multitude of cellular responses, including cortical plaque formation [3], release of intracellular calcium [5], [6] and anti apoptotic factors [7], [8].
Hydrogen peroxide has also been shown to mediate host cell death.
The A subunit mediates host cell targeting and specificity of the toxin complex through membrane receptor binding of insect intestinal cells [ 89, 91, 93].
CagL (HP0539), which shows some sequence similarity to VirB5, was shown to mediate host cell recognition or adhesion (Kwok et al., 2007).
Strikingly, the Lepidopteran ortholog of Drosophila breathless [fibroblast growth factor receptor (FGFR) in mammals] is a receptor for the baculovirus FGF, which mediates host cell chemotaxis and presumably tracheogenesis of the midgut (Katsuma et al., 2006).
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