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Here we elucidate the mechanisms underlying IFNγ/IRGs-induced immunity to C. trachomatis in murine cells, demonstrating a pivotal role for Irga6 in mediating host resistance to infection via the induction of autophagy.
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By including appropriate mutants in this study, we identified components of the ABA hormonal pathway that act downstream of WRKY33 to mediate host resistance.
Wheat R2R3 MYB TF (TaPIMP1) mediates host resistance to fungal pathogen and drought stresses by regulating defense-related genes (PR1 and PR5 genes) through ABA- and SA-signalling pathways [ 60].
It is a cytoplasmic protein expressed in peripheral blood monocytes, Paneth cells and intestinal epithelial cells, and is structurally related to the well-described R proteins in plants, which mediate host resistance to microbial pathogens [ 14].
IAPs were described critical in mediating host cell viability.
Our results provide new insights on how Wolbachia affects its hosts through mediating host miRNAs.
Genotype by genotype interactions — with host polymorphism for resistance and viral polymorphism for overcoming that resistance — may be indicative of negative frequency-dependent selection or incomplete on-going selective sweeps in the virus, driven by selection mediated by host resistance.
GP1 mediates host cell attachment and receptor recognition, whereas GP2 mediates fusion of the viral and host membranes8,9,10,11,12.
We conclude that estrogen mediates greater host resistance to pneumonia in female mice via effects on the constitutively expressed NOS3 in lung macrophages.
Their role, which is hitherto unknown, could for example be to provide resistance to yet unknown pathogens and/or to mediate non-host resistance responses [ 2].
Interferon (IFN -inducible guanylate bIFN -inducibles (guanylateiate cell-autonomous host resistance to bindingal proteinss and promote inflammasome activation.
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