In AD transgenic models in which ADAM10 is over-expressed, β-secretase mediated processing of APP decreases, amyloid plaque formation is lessened, and the cognitive capacities of the dual transgenic animals is improved [55].
Deficits in proteolytic degradation and protein quality control observed in AD patients may promote protein aggregation [12], and subsequent ER stress induction, which could decrease γ-secretase mediated processing of APP in sporadic AD patients.
As a γ-secretase catalytic subunit, increased PS1 expression has often been found to occur simultaneously with augmented γ-secretase activity [67], while repression of PS1 transcription inhibited γ-secretase mediated processing of APP [68].
As discussed above, Aβ is produced through the β and γ-secretase mediated processing of APP.
As for many other enveloped viruses, the morphogenesis of filoviruses appears to depend upon ER α-glucosidases mediated processing of envelope glycoproteins.
In this noncanonical pathway (Fig. 1B), IKKα mediated processing of p100 results in the nuclear translocation of RelB-p52 heterodimers, and plays a key role in B-cell mediated adaptive immunity (Senftleben et al., 2001).
