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The systematic study of identifying co-regulating miRNAs showed that specifically regulated processing of pre-miRNAs may have caused selection of distinctive structural features that are involved in discriminating regulatory interactions.
Although these cases could be simple annotation artifacts, it is also possible that they reflect regulated processing of pre-miRNA that results in preferential utilization of different arms of miRNA precursor [15], [20].
Bhutia et al. showed that lin28 and SET regulated processing of let-7a in pancreatic cancer cell lines.
The discovery of many RNA-binding protein domains [ 9, 18], regulated processing of cytoplasmic RNAs [ 19], and conserved regulatory elements in 3' untranslated regions (3'UTRs) [ 14, 20- 23] are hard evidence that corroborate this statement.
Moreover, DALIS formation coincides with a delayed presentation of antigens on the cell surface, which led to the proposal that DALIS represent functional sites in DCs for the storage and regulated processing of antigens [21], [31], [32].
These results show that regulated processing of sqt pre-mRNA requires maternal Ybx1 function.
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The unique lincRNA H19 (half-life ~ 1 h) is abundantly expressed during embryonic development and down-regulated after birth and can regulate processing of miR-675 [ 18, 52].
Additionally, commonly observed gut microbial transcripts in our study encode for proteins that enable binding to host epithelium, regulate processing of extracellular polysaccharides, and mediate microbial stress response.
In order to assess whether PTB regulates processing of the fosB pre-mRNA, in vitro splicing assays were performed with transcripts prepared from constructs containing the ISS/wild type sequence or the ISS/T6 mutation (Fig. 4B).
Cleveage and polyadenylation specificity factor 6 (Cpsf6) regulates processing of long noncoding RNAs (Naganuma et al. 2012).
TLR-L regulate processing of the invariant chain (Ii) and influence the exchange of CLIP with antigenic peptides.
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