Sentence examples for mediated decay of from inspiring English sources

However, the FBN1 mutation in that family lead to nonsense mediated decay of the mutant transcript, not being able to exert a dominant-negative effect.

We previously used this methodology to show that BM specimens had predominant expression of either A or B alleles relative to the O allele, probably due to nonsense mediated decay of the O allele [41].

Even though it is transcribed in cells other than neurons, a PTB-induced exon skipping event leads to Nonsense Mediated Decay of the bulk of nPTB mRNA in non-neuronal cells [24], [25].

Using in situ hybridization (ISH) we also found that the level of dbh mRNA in dbh−/ − larvae is much lower than in their dbh+/ − siblings, presumably due to nonsense mediated decay of the mutant transcript (Isken and Maquat, 2007).

As the myotonia observed in DM1 has been hypothesized to result primarily from Clc-1 splice errors and a concomitant reduction of RNA steady-state levels due to nonsense mediated decay of aberrantly spliced Clc-1 RNAs (Mankodi et al., 2002) we tested if Clc-1 splice defects are enhanced in Mbnl1 ΔE3/ΔE3/mice3 ΔE2 mice.

The mutation results in non-sense mediated decay of the HACD1 mRNA to 31% of control levels in patient muscle and completely abrogates the enzymatic activity of dehydration of 3-hydroxyacyl-CoA, the third step in the elongation of very long-chain fatty acids (VLCFAs).

Therefore, MazF-mediated decay of host factors could impact circuit functions.

We show that disruption of DISC1 near the site of the translocation results in decreased DISC1 protein levels because of nonsense-mediated decay of long splice variants.

In strains showing reduced message levels, we have identified an intronic SNP that activates a cryptic splice site leading to aberrant splicing, followed by nonsense-mediated decay of the message.

Generally, low levels of CHM mRNA could be explained by nonsense-mediated decay of the transcript [31].

Matsui et. al. [13] have reported that Bim-mediated apoptosis is prevented in an IL-3 dependent B-cell line by IL-3-mediated decay of Bim transcript.