Sentence examples for mediate translational repression from inspiring English sources

These observations strongly suggest that miR-130a is acting through the A site of the FOG-2 3'UTR to mediate translational repression.

The G-quadruplex was modeled on one previously described to be present within the 5' UTR of NRAS RNA and shown to mediate translational repression [23].

To demonstrate that miR-130a is required to mediate translational repression via site A in the FOG-2 3' UTR, we took two approaches.

These findings further indicate that other factors may contribute to or modulate the functionality of PUM binding sites, for example recognition elements for cofactors like Nanos, which is known to interact with Pumilio to mediate translational repression [55].

MiRNAs have primarily been demonstrated to mediate translational repression or target gene degradation and silencing.

By base pairing to mRNAs, microRNAs mediate translational repression or mRNA degradation [ 19].

We next used the polysome profiling assay to confirm that eIF4E2 participates in miRNA mediated translational repression.

Notably, let-7a overexpression reduced the total mRNA level of fLuc-LRE but not the control reporter RL, while downregulation of eIF4E2 did not affect the total mRNA level of either reporter (Fig. 4C), indicating that eIF4E2 mainly plays a role in the process of miRNA mediated translational repression but not the process of RNA decay.

In addition, it is subject to miRNA mediated translational repression [58].

We also used a gain of function approach to demonstrate miR-130a's role in mediating translational repression of FOG-2.

In the same study, these authors also suggested a systematic translational repression of truncated proteins from frameshift mutation-derived mRNAs that escaped NMD NMTRR for "Nonsense Mediated Translational Repression") [23].