Sentence examples for mediate immune tolerance from inspiring English sources

Immune checkpoints are pathways that dampen inflammatory responses and mediate immune tolerance toward normal tissue.

The expression of T-regulatory cells, which mediate immune tolerance and abrogate excessive inflammation, is linked to Foxp3 gene expression.

Following the studies in thymus, cells capable of expressing self-molecules and mediate immune tolerance were described in peripheral lymphoid tissues as well [ 60 ].

Th17 cells are a subpopulation of CD4+ T cells that mediate inflammatory responses, while Treg cells are a type of negative immune regulatory cells that mediate immune tolerance.

As such, establishing how MSCs act within a diseased environment and, more specifically, how they mediate immune tolerance in lupus patients, is pivotal to improving our understanding of MSC transplantation and identifying the patients in whom an MSC transplant would provide the most clinical benefit.

Barth, S.D. et al. Treg-mediated immune tolerance and the risk of solid cancers: findings from EPIC-Heidelberg.

Given IL-1's known effects to promote T cells responses, our findings on IL-1β regulation by α-Syn variants in innate immunocompetent cells require further attention in view of the potential effects of the latter in mediating immune tolerance and T effector responses.

Programmed death-1 (PD-1) plays an important role in mediating immune tolerance through mechanisms that remain unclear.

Exosomes are variously involved in immune system functions and show either stimulatory or inhibitory effects, acting in antigen presentation or mediating immune tolerance [ 38, 39 ].

Development of pancreatitis in Tgfbr2 fspKO DC chimeras indicated that TGFβ signalling in S100A4-positive myeloiDCsCs is required to prevent development of mAIP and supports a role for TGFβ signalling in DC-mediated immune tolerance.

On the other hand, it is tempting to speculate that some of the beneficial clinical activity of idelalisib in CLL may be related to breaking Treg-cell-mediated immune tolerance to the CLL cells, as recently described in mouse models of solid tumors (Ali et al. 2014).