Sentence examples for mediate immune cell from inspiring English sources
Furthermore, they mediate immune cell trafficking and play a key role in immunomodulation9.
The tail region of an antibody, containing two heavy chain constant domains, that interacts with Fc receptors (FcRs) to mediate immune cell effector functions.
These receptors mediate immune cell responses to a family of soluble chemo-attractant molecules, termed chemokines.
Activating FcγRs (FcγRIIA, FcγRIIC, FcγRIIIA, and FcγRIIIB) mediate immune cell activation promoting inflammation, while the classic inhibitory FcγRIIB dampens immune responses and restricts inflammation (1, 2).
In particular members of the tumor necrosis factor (TNF) superfamily, such as, TNF α and Fas (CD95) ligand have been shown to mediate immune cell-mediated damage of the intestinal epithelium.
Furthermore, while PD-1T lymphocytes were impaired in classical effector cytokine production, they produced CXCL13, which mediates immune cell recruitment to tertiary lymphoid structures.
Upon inflammatory stimulation of endothelial cells (EC), JAM-A redistributes from tight junctions to the apical cell surface where it mediates immune cell adhesion in vitro under static and flow conditions [10], [11], [12], [13], [14].
S1PR1 is a member of the G-protein-coupled receptor for sphingosine-1-phosphate (S1P), a chemokine mediating immune cell migration [ 19, 20].
Previous studies have shown that endothelium-derived NO is a potent anti-inflammatory molecule, suppressing the expression of chemokines and adhesion molecules mediating immune cell infiltration [ 49].
These ligands bind to the principal death receptors Fas, TNFR-1, TNFR-2, DR3 and DR4, which initiate apoptosis in cell mediated immune cell death and in a variety of physiological and pathological situations.
While much has been learned regarding the sequential steps of immune cell rolling or capture, adhesion and crawling on the BBB, the cellular pathways and the molecular cues mediating immune cell diapedesis across the BBB are only just being unraveled (summarized in [ 6, 19]).
