Sentence examples for mediate functional interactions from inspiring English sources

In particular, recent explorations of physical arrangements and chromatin landscapes in higher eukaryotes have demonstrated that chromatin insulators, which mediate functional interactions between regulatory elements, appear to play an important role in these processes.

In addition to this arrestin core, five of the Dictyostelium Adc proteins exhibit at least one extra domain that is expected to mediate functional interactions with either lipids (C2 domain in AdcB and -C, FYVE domain in AdcA and -D) or proteins (SAM domain in AdcB and -C, MIT and LIM domains in AdcE) (Table S1).

SH2 domains may mediate functional interactions with DNA binding proteins.

Thus, mitochondrial tethers mediate functional interactions between the ER and mitochondria that are critical for many key cellular homeostatic pathways.

In mammals, these approaches may be slightly less informative than assays detecting gene expression changes, because only one out of four AGO proteins (AGO2) has the ability to cleave mRNA targets, although all AGOs mediate functional interactions 13, 95.

These molecules are produced within the mammary tissues proper and they act over very short distances, often in a paracrine manner, to mediate functional interactions between the stromal and epithelial compartments of the gland [ 63].

Till, S. et al. A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.

In contrast, the non-informational groups might not experience such lineage-specific differences in selective pressure as they usually catalyze individual reactions in metabolic pathways with the flux of substrates mediating most functional interactions between them.

Our data further indicate a previously unappreciated requirement for mural cell Cx43 expression and gap junction activity in mediating the functional interactions required for maintenance of endothelium in a quiescent state.

PABP1 comprises four non-identical RRMs (RNA recognition motifs), a proline-rich region and a PABC (PABP C-terminal domain) (also known as MLLE) and, although many binding sites await further definition, it is clear that each domain mediates important functional interactions.

Integrins are cell surface adhesive receptors composed of α- and β-chain heterocomplexes that mediate physical and functional interactions between cells and the extracellular matrix.