Sentence examples for mediate distinct cellular from inspiring English sources
Menin is phosphorylated at two Ser residues, Ser543 and Ser583, and it is possible that post-translational modifications may mediate distinct cellular functions [26].
p75NTR is a cell-surface receptor that can bind a variety of different ligands to mediate distinct cellular functions.
Conversely, a given growth factor receptor can employ distinct signalling effector pathways to mediate distinct cellular responses.
Some SG-resident proteins mediate distinct cellular responses to stress that are dependent on the type of stress encountered 49505151.
Given that IRS-1 and IRS-2 mediate distinct cellular responses to IGF-1stimulation, their relative expression levels and functional status are likely to impact the response of tumors to therapies that target the IGF-1 signaling axis.
The p75NTR (where NTR is neurotrophin receptor) can mediate many distinct cellular functions, including cell survival and apoptosis, axonal growth and cell proliferation, depending on the cellular context.
Thus, it is likely that the deleterious effects of radiation on these two phenotypes are mediated by distinct cellular mechanisms.
Introducing point mutations in the genomic loci of RTKs, such as TrkC, TrkB, Met, Pdgfr or Ret, by selectively modifying the binding sites through which they recruit cytoplasmic effectors, has been instrumental in distinguishing the respective contribution of signalling adaptors, such as PLCγ, Shc, Grb2, PI3K and Src, in mediating qualitatively distinct cellular responses in vivo [ 7– 12].
Taken together, our findings indicate that different transport mechanisms and/or distinct cellular sources mediate hypoosmotic medium-induced release of the excitatory amino acids and taurine in vivo.
Such widespread degradation may also indicate a role for programmed cell death of a distinct cellular subpopulation, in mediating the changes at the metabolic switch.
The rough landscape of STAT6-responsive sites was found to be shaped by chromatin structure, but distinct cellular responses were mainly mediated by distinct sets of transcription factors.
