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Mast cells have Toll-like receptors and interact with dendritic cells, B cells, and T cells to help mediate adaptive immune functions.
However, their potency to mediate adaptive immune response was not affected.
Agonist binding by these receptors results in changes in signal transduction that can lead to establishment of antiviral responses as well as mediate adaptive immune responses.
The above results prompted us to check whether Jak2 deficiency would affect the capability of DCs to mediate adaptive immune response.
Epithelium-derived cytokines recruits dendritic cells, T cells and B cells into close proximity of epithelium to mediate adaptive immune response through interaction with epithelial cells.
However, their potency to mediate adaptive immune response such as the capacity to activate allogenic or antigen specific T cells was not affected (Figures 3A C).
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Other than their well-recognized role in mediating adaptive immune response, they also serve as a key component of innate immunity and bridge innate and adaptive immune response to bacteria and other pathogens [2] [4].
Kang et al. [ 117] have confirmed that pre-malignant senescent hepatocytes secrete chemo- and cytokines and are subject to immune-mediated clearance ("senescence surveillance") that strictly depends on an intact CD4+ T-cell-mediated adaptive immune response.
Particulate vaccines are inherently immunogenic due to enhanced uptake by antigen presenting cells which process antigens mediating adaptive immune responses.
Danger signals such as toll-like receptor (TLR) agonists induce maturation of DC leading to a T-cell mediated adaptive immune response.
Their crucial interaction with T-cell receptors on cytotoxic T-lymphocytes (CTLs) mediates adaptive immune responses against viruses and intracellular parasites [1], [2].
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