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Other than their well-recognized role in mediating adaptive immune response, they also serve as a key component of innate immunity and bridge innate and adaptive immune response to bacteria and other pathogens [2] [4].
Particulate vaccines are inherently immunogenic due to enhanced uptake by antigen presenting cells which process antigens mediating adaptive immune responses.
The "classical" HLA class I and II gene products are involved in endogenous and exogenous antigen presentation respectively, mediating adaptive immune responses to pathogens and tissue transplants.
As well as mediating adaptive immune functions, IL-12 has angiostatic effects (Duda et al, 2000), and histological evaluation of tumours from mice treated with Neuro-IL2/IL12 or AJ-IL2/IL12 vaccines suggested that the vascularisation was reduced compared to control tumours.
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Mast cells have Toll-like receptors and interact with dendritic cells, B cells, and T cells to help mediate adaptive immune functions.
However, their potency to mediate adaptive immune response was not affected.
Danger signals such as toll-like receptor (TLR) agonists induce maturation of DC leading to a T-cell mediated adaptive immune response.
The above results prompted us to check whether Jak2 deficiency would affect the capability of DCs to mediate adaptive immune response.
Epithelium-derived cytokines recruits dendritic cells, T cells and B cells into close proximity of epithelium to mediate adaptive immune response through interaction with epithelial cells.
However, their potency to mediate adaptive immune response such as the capacity to activate allogenic or antigen specific T cells was not affected (Figures 3A C).
Their crucial interaction with T-cell receptors on cytotoxic T-lymphocytes (CTLs) mediates adaptive immune responses against viruses and intracellular parasites [1], [2].
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