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T-cells, which mediate cellular immune responses, can target more conserved peptides from internal proteins and have the potential to provide wider protection.
In contrast, T cells, which mediate cellular immune responses, can target internal proteins common to heterologous viral strains.
In contrast, T cells mediate cellular immune responses and recognize foreign antigen only when presented by major histocompatibility complex (MHC) molecules on the cell surface of antigen presenting cells (APCs) [ 38, 39].
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Th1 cell mainly produced IL-2, IFN-γ and TNF, mediating cellular immune response and involving in delayed type hypersensitivity [ 26].
T cell mediated cellular immune response after DNA vaccination were analyzed using flow cytometry analysis of the percentages of CD4+ and CD8+ T cells in the spleen of immunized mice.
At present, the prevailing explanation is that the DNCB-induced CHS is a condition predominantly mediated by cellular immune responses [4] [7].
T cell receptor An antigen-binding protein that is located on the surfaces of killer T cells and mediates the cellular immune response of mammals.
These findings suggest that protection was at least partially mediated by a cellular immune component and that the induction of Th2 and immunoregulatory cytokines by a KIN1148-adjuvanted vaccine may be particularly beneficial for ameliorating the immunopathogenesis that is associated with influenza viruses.
This ML domain is also a key domain in the human proteins MD-1 and MD-2 (myeloid differentiation factors), where it binds bacterial lipopolysaccharide (LPS) and mediates cellular innate immune responses to LPS through co-interactions with toll-like receptor 4 [ 86– 86].
Humoral immune responses are represented by the production of antibodies that bind to the surfaces of bacteria and viruses, whereas cellular immune responses mediate immunity to intracellular pathogens.
In vivo LAP utilized an IL-10-dependent pathway to mediate suppression of the cellular immune response.
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