Sentence examples for mechanisms including mutation from inspiring English sources

These alterations occur by multiple mechanisms, including mutation, loss of heterozygosity (LOH) and promoter hypermethylation.

In all cell lines used in this article, p53 function is lost by different mechanisms, including mutation and loss of expression and function.

Therefore, imatinib resistance in AR cells can be caused by complex and dynamic mechanisms, including mutation in the BCR/ABL1 gene.

Strain variation can arise through several mechanisms, including mutation, genomic rearrangements, inter and intragenic recombination, or acquisition of genes from mobile genetic elements including transducing bacteriophages.

The phosphatidylinositide 3-kinase (PI3K) pathway is activated in about half of head and neck squamous cell carcinomas (SCC) by a number of mechanisms, including mutation or amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA)[ 1- 4].

Indeed, loss of PTEN function occurs in a wide spectrum of human cancers through a variety of mechanisms, including mutations, deletions, transcriptional silencing, or protein instability.

This could be attributed to several mechanisms including mutations in the viral genome, inhibition of the presentation and processing of certain epitopes, and/or the inability of the T cells to adequately respond to survival signals.

TKRs may become dysregulated by several oncogenic mechanisms including mutations, protein overexpression and increased gene copy number.

The molecular evolution of R genes is thought to be affected by several mechanisms, including mutations caused by transposable elements (TEs).

Such data could explain why the Cry1AMod protoxins can counter different resistance mechanisms including mutations in other receptors that might be involved in toxin oligomer membrane insertion.

Canonical Wnt signaling can be constitutively activated in cancer by a variety of mechanisms including mutations in adenomatous polyposis coli (APC), Axin, and β-catenin [ 47].