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Further, molecular mechanisms underlying cellular responses to mechanical stimulation are not well understood.
The mechanisms by which bone senses and responds to mechanical stimulation are complex and occur at a number of hierarchical levels.
The impact of scaffold content and configuration, the contribution of endogenous and exogenous bioactive factors, the influence of the host immune response and the functional interaction with mechanical stimulation are all considered.
Importantly, the results of this study reveal that systemic and readily controllable cues, such as scaffold alignment and optimized mechanical stimulation, are sufficient to drive MSC differentiation, without the need for additional chemical stimuli.
Furthermore, the combination of scaffold geometry, biochemical, and mechanical stimulation are thought to affect SMC phenotypes.
It has been argued that both chemical and mechanical stimulation are needed for the acquisition of pathological active fibroblasts (Hinz, 2007).
Similar(53)
Mechanotransduction — the mechanism by which a mechanical stimulation is transduced into a chemical signal — typically involves force-induced conformational changes in proteins or altered affinities to their binding partners but these interactions remain largely unexplored.
In contrast, c-Fos, a gene indicative of mechanical stimulation, was upregulated in the marrow cells of mechanically stimulated explants, while the level of activated c-Jun decreased by 25%.
However, the pattern of decreased glycogen and increased triglycerides seen after mechanical stimulation was not seen in females stimulated by light.
Another example of this combined receptor mechanical stimulation was demonstrated by Haj and his colleague by targeting PDGFRα and PDGFRβ.
Mechanical stimulation was the most viable option for collecting saliva without affecting the levels of CRP and myoglobin.
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