Mechanical trauma is an injury to any portion of the body from a blow, crush, cut, or penetrating wound.
Nonlethal mechanical trauma was characterized by the 100% survival rate during the first 24 h after trauma, the lack of circulatory shock and without direct heart injury.
However, when skeletal muscle is damaged by unaccustomed exercise or mechanical trauma, they are activated to proliferate, differentiate, and fuse with the already existing muscle fibers or fuse to form new muscle fibers [ 75, 84].
In younger people without genetic/developmental abnormalities, mechanical factors due to trauma are primarily implicated in the initiation and progression of OA lesions [12].
We could speculate that one of the mechanism involved in the induction of the irreversible neurodegeneration observed in ALS after mechanical trauma, could be the over-expression of structural genes in individuals with a genetically-determined inability of clearing these products in a way that would prevent the formation of cytotoxic cellular aggregates.
This mechanical trauma can be prevented by modifying the surface of surgical instruments to increase adhesion to the ILM.
This study provides further insight into the toxic effects induced by a SOD1 gene mutation, showing how the molecular response to a mechanical trauma can be profoundly modified by this genetic defect in an otherwise pre-symptomatic rat.
There is mechanical trauma which could be caused by chronic eye rubbing, as well as a result of poorly fitted rigid contact lenses [ 104, 118, 119].
A lesion of an eruption that subsequently develops where a mechanical or other physical trauma was applied is termed an isomorphic reaction.
Maternal mechanical trauma in pregnancy is a risk factor for hypoxic ischemic brain injury and can potentially affect the CNS and fetal motility.
