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AS supervised the tendon mechanical loading protocol and carried out the imaging and histological examination.
To induce a mechanical loading protocol on a single cardiomyocyte, carbon fibers can be moved leading to isometric or shortening contractions.
All Achilles tendons analyzed from animals subjected to the mechanical loading protocol demonstrated microregions of abnormal tenocyte morphology, typified by the appearance of tenocytes with prominent cytoplasm and rounded morphology.
Runners were subjected to a previously published mechanical loading protocol (Rat-A-PED) using a dedicated rat treadmill to induce Achilles tendinosis (Exer 3/6, Columbus Instruments, Columbus, OH) [ 15].
The wavelength scans of both normal tendon from sedentary rats, and of tendon surrounding abnormal tenocytes from rats subjected to the mechanical loading protocol, showed a highly specific SHG signal manifested by a narrow peak at 440 nm.
Similar(55)
This is also a practical simplification as transmission images with sarcomere length information additionally contain carbon fiber positional information that is needed for mechanical loading protocols.
To our knowledge, there are no data available on fiber type-specific expression of p38 and JNK except in response to various activity protocols (see " Mechanical loading").
For other factors affecting the rate of translation initiation and elongation, only indirect information is available from experiments studying the fiber type-specific expression and activation of these factors in response to various exercise protocols (see " Mechanical loading").
Other potential mechanisms include cumulative mechanical loading and micro-trauma and proprioceptive deficits.
We used a loading protocol well described for mechanical evaluation of distal femur fractures [ 19– 219.
Therefore, the present meta-analysis emphasizes the adaptive potential of tendons to increased mechanical loading, which was quite consistently shown despite the marked variety of loading protocols.
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mechanical loading provides
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