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However, while CC16 levels remained unchanged over time, SP-D and KL-6 levels increased in ALI/ARDS patients when ventilated with a conventional mechanical ventilation protocol.
In the next step we investigated the relation between mechanical ventilation protocol and plasma protein levels.
To investigate whether mechanical ventilation protocol would influence protein levels, a second linear mixed model was constructed in which changes in protein levels over time were studied while controlling for mechanical ventilation protocol (conventional or protective).
Design: A retrospective cohort equivalence study linking a national survey of mechanical ventilation protocol availability with knowledge about mechanical ventilation.
The use of a lung protective mechanical ventilation protocol was the factor most likely to be associated with use of appropriate tidal volumes in ALI patients [ 10].
In multivariate analysis, both SP-D and KL-6 levels were significantly influenced by mechanical ventilation protocol (P = 0.04) while presence of pneumonia was not significantly associated.
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Objective: To study the relationship between critical care training with mechanical ventilation protocols and subsequent knowledge about ventilator management.
ALI/ARDS patients were randomized to one of two mechanical ventilation protocols as described previously [ 4].
Thus, while mechanical ventilation protocols have been shown to improve outcomes [ 1- 3], they cannot replace clinical judgment.
As mechanical ventilation protocols were different amongst patients with and without ALI/ARDS, this analysis was performed for each group separately.
The damage caused by high concentrations of inspired oxygen and aggressive mechanical ventilation protocols has promoted this philosophy mong pediatric critical care physicians [ 35].
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