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Prior studies demonstrating the ability to lengthen intestinal segments with mechanical force required devices with extracorporeal components.
Also, it represents the magnitude of mechanical force required for cell migration driven by actin and microtubule accumulation as well.
Contraction of actin-myosin cytoskeletal structures generates the mechanical force required for cell motility and invasion [ 2].
Single molecule studies using optical tweezers to pull pseudoknots apart [ 37– 39] showed that the mechanical force required to unfold pseudoknots is much larger than the Gibbs free-energy difference (Δ G) between folded and unfolded pseudoknots.
Based on the increased mechanical force required to remove the rachis and awns from the seeds we hypothesize that the thresh-1 gene is involved in altering the cell wall composition of the spike.
Two main hypotheses have been proposed [ 140], one assuming that constant growth of a branched actin meshwork propels invadopodia into the underlying matrix, similar to lamellipodia protrusion, while the other suggests that the mechanical force required to overcome substrate stiffness is provided by actin bundles originating from the branched network, akin to filopodia formation.
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The mechanical forces required to perforate cardiac walls with an ablation catheter were also evaluated in an animal model.
Larger root biomass increases the magnitude of the mechanical forces required to dislodge a plant from its substrate [51].
Alternatively, presence of PA may act as a signpost for the recruitment of proteins and complexes that can apply mechanical forces required for membrane tubulation.
During this period the leaf cell wall undergoes dynamic changes to allow cells to expand, but at the same time cells must maintain the mechanical strength required to resist the forces of turgor pressure [ 25].
Notably, vinculin also binds α-actinin, and molecular dynamics modeling suggests that mechanical force is required to expose the vinculin-binding site on α-actinin.
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