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The residues of these motives transform the chemical energy derived from ATP hydrolysis into a mechanical force necessary for helicase movements for the disruption of ssRNA or RNA base pairs.
These observations are consistent with a model in which F-actin dynamics are needed in the invagination stage of endocytosis to provide the mechanical force necessary to overcome osmotic pressure in yeast, something not quite relevant to mammalian cells.
In the Aquiflex aeolicus PilT structure (Satyshur et al, 2007), it was proposed that a 15 Å movement of the C-terminal domain observed upon nucleotide hydrolysis and γ-phosphate release would be sufficient to provide the mechanical force necessary to extract pilin subunits from the pilus during disassembly.
Similar(57)
This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling.
Dynamin has long been regarded as a mechanoenzyme which provides the necessary mechanical force to pinch off the endocytic vesicle by neck constriction.
It is necessary to collect the information of mechanical force distribution at different levels, and map the cross-talks between mechanical forces and biological functions.
The source of this extrinsic mechanical force remains unknown.
No perverted manipulation or overbearing force necessary.
Why was that level of force necessary?
We load DNA into the confinement from the top, without the need of any mechanical force, overcoming complex mechanical loading.
This generated a mechanical force that stretched the polymers apart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com