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GFR and RBF were measured using inulin and PAH, respectively, according to established methods.

In the first two studies, GFR was measured using inulin clearance.

Glomerular filtration rate (GFR) was measured using inulin clearance and effective renal plasma flow (ERPF) using para-aminohippurate clearance.

Eleven subjects received 5-hour infusions of relaxin that led to serum concentrations approximating those seen in pregnancy, and GFR and RBF were measured using inulin and para-aminohippurate, respectively.

Euglycemic (blood glucose 4 6 mmol/l) and hyperglycemic (blood glucose 9 11 mmol/l) conditions were maintained on two consecutive days using a modified glucose clamp technique, and renal hemodynamic function was measured using inulin and para-aminohippurate (6, 7).

Similar(55)

Moreover, accurate GFR measurements using inulin or iothalamate infusions are undoable for large scale study populations.

Glomerular filtration rate (GFR), measured using exogenous substances such as inulin, iohexol, I-iothalamate, diethylene triamine pentaacetic acid and chromium-ethylenediaminetetraacetic acid (Cr-EDTA) as filtration markers, is considered as the gold standard for assessment of renal function [ 9, 10].

In the latter, K in csf was measured using a 30-minute time-point for inulin (a large molecule expected to diffuse 4 times less than sucrose across brain barriers), was 0.17 × 10−3 min−1 [ 21].

For C-inulin measurements, samples were mixed with 5 mL of scintillation cocktail then dpm was measured using a Wallac 1414 Liquid Scintillation Counter.

Ideally GFR would be measured using reference procedures which follow the clearance of an infused exogenous substance (e.g. inulin, I-iothalamate or iohexol [ 5]).

Reasons for this potential difference may include the fact that both Shemesh and Bauer measured GFR using inulin clearance rather than iothalamate clearance and the former is known to be lower than the latter [ 21].

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