Ai Feedback
Exact(5)
However, most studies only measured total adiponectin rather than its high-molecular-weight multimer (12 18mer), which may be more biologically active than trimer and hexamer [6], [7], [8].
Second, we measured total adiponectin concentration, and not that of individual isoforms.
The present study measured total adiponectin rather than the high-molecular-weight adiponectin (deemed the biologically active form).
Finally, the assay used for determination of adiponectin concentrations measured "total" adiponectin and, thus, was not able to differentiate the different isoforms of the protein, the distributions of which have been shown to differ by ethnicity.
We measured total adiponectin and not the high molecular weight fraction, which has been proposed to have substantially more potent effects on hepatic insulin sensitivity compared with total adiponectin [ 79].
Similar(55)
The other limitation is associated with measuring total adiponectin concentrations, rather than its different molecular forms.
In addition, in the GHS-prospective design, very similar data were obtained with HMW-adiponectin, the biological active form of circulating adiponectin, thus reinforcing data obtained by measuring total adiponectin levels.
The RIA used in the current study measures total adiponectin and the impact of mild GDM and treatment on various forms of adiponectin may give more insight into the likely impact of any changes on fetal and infant growth and metabolism.
Finally, studies conducted to date in RA measured exclusively total adiponectin and not its isoforms, and the discrepancies between the findings of these studies may be explained by the distinct biological properties of the different adiponectin isoforms.
Firstly, adiponectin exists in the circulation as three isoforms: trimers, hexamers, and high molecular weight (HMW) forms, potentially with different biological activity [ 43, 44], but the present study only measured the total adiponectin concentration.
We have no explanation for the lack of changes in this adipokine; perhaps it is because we measured only total adiponectin and not its active high molecular-weight form.
Related(20)
evaluated total adiponectin
measured total glycogen
measured total fracture
measured total cross
measured total ammonia
measured total aboveground
measured total metal
measured total serum
measured total insertion
measured total energy
measured total protein
measured total transverse
measured total dendritic
measured total leucocyte
measured total insulin
measured total dietary
measured total cholesterol
measured total intake
measured total steroid
measured total testosterone
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com