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Exact(5)
Of note, the glomerular density was found to be inversely correlated with the mean glomerular volume in these patient cohorts.
At equivalent MAP, the male rats exhibited far more renal injury than the females as measured by the glomerular sclerotic index, mean glomerular volume, and proteinuria [ 58].
Although measurements of the cortical glomerular volume fraction and mean glomerular volume in individuals are most accurate for calculating the glomerular density, such analyses are unfortunately very time-consuming and therefore a difficult to routinely perform in general clinical situations.
Previously, estimating the total glomerular number was accomplished by a combination of magnetic resonance imaging (MRI) and a biopsy to measure the cortical glomerular volume fraction and mean glomerular volume [ 16, 17].
In addition, in spite of the fact that measuring both the cortical glomerular volume fraction and mean glomerular volume are considered to be appropriate parameters to accurately estimate the total glomerular number in individual patients, these are also unrealistic, because these procedures are very time-consuming.
Similar(55)
Augmented nephron endowment was accompanied by significant decreases in mean glomerular volumes (p<0.05).
Finally, the total number of glomeruli (Ntotal) was calculated as: N total = Total glomerular volume one average glomerular volume = V F glom/cortex × V Cortex 4 3 π r 3 Where Vcortex is the volume of the cortex estimated by MRI.
In this study, however, mean glomerular and mesangial volumes were significantly increased in the placebo group compared with the enalapril group after 5 years of follow-up.
Low-level lead exposed mice [BLL mean (SD); 3.19 (0.70) μg/dL] had an increase in glomerular volume but no change in podocyte number compared to control mice [0.03 (0.01) μg/dL].
The increase in glomerular volume was explained by increases in glomerular capillary and mesangial volumes with no change in podocyte volume.
Mean glomerular filtration rate estimated with the MDRD-4 (eGFR MDRD) formula was 48.93 ± 26.46 mL/min/1.73 mL/min/1.73
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