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Exclusion criteria for the whole experiment were: mean weights of all foetuses, <20 g or >40 g; non-treated controls, mean tidal volume at 5 min >5.5 ml kg−1; positive controls (Curosurf-treated), mean tidal volume at 5 min <11 ml kg−1.
Despite the small sample size, the results of dependent t tests revealed statistically significant improvements, using an alpha level of 0.05, in the mean tidal volume and negative inspiratory force values at the 30-minute measurement, and in the vital capacity value at the 15-minute measurement.
This volume trapped was accommodated during the first four CPAP breaths, after which mean tidal volume inspired and mean tidal volume expired did not differ significantly.
50% of units had a mean tidal volume of >8ml/kg.
During the first twenty breaths during CPAP the difference between mean tidal volume inspired (862 ± 235 ml) and mean tidal volume expired (831 ± 875 ml) was 31 ml, and the volume trapped was approximately 600 ml.
Mean tidal volume and PEEP in initial ventilator mode was 7.30 ± 1.93 mL/kg (predicted body weight, PBW) and 6.02 ± 0.97 cmH2O.
Similar(9)
Every unit had mean tidal volumes >6ml/kg IBW for both CMV and ASB ventilation.
However, control group ventilation strategies did not achieve the full range of traditional tidal volumes; mean tidal volumes were consistently at the lower end of the traditional range.
Reported mean tidal volumes in control and pressure and volume limited groups ranged from 9.8 to 12 mL/kg and 6.1 to 9.0 mL/kg, respectively, while the between group gradient in achieved tidal volume ranged from 2.0 to 5.6 mL/kg over the first week of study.
Of note, more than one-third of ALI patients in that cohort had mean tidal volumes greater than 8 cc/kg [ 19].
However, the CV group in this trial received mean tidal volumes of 10.2 ml/kg, which more recent evidence [ 1] suggests is too large and hence detrimental.
More suggestions(16)
mean tidal range
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