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These changes represent common molecular features of drug abuse, which may underlie changes in synaptic function and plasticity that could have important ramifications for decision-making capabilities in drug abusers.
Thus, our finding that RXLR effector genes are commonly amplified, and that allelic variation in copy number may underlie changes in virulence, provides further evidence of the rapid evolution of this super-family.
A similar mechanism may underlie changes in the hepatic perfusion index in patients with liver metastases.
Similar rapid variations may occur during normal intracortical communication and may underlie changes in the cortical organization of function.
Our peptide array data also imply that interdomain interactions between the NTD and LBD are altered by TARPs, which may underlie changes in desensitization rates observed in response to linker truncation.
Likewise, in-depth electrode studies in humans show that changes in thalamic activity during sleep precedes changes in cortical activity, suggesting that disrupted thalamo-cortical functional connectivity may underlie changes in consciousness (Magnin et al., 2010).
Similar(51)
Relatively modest changes in the CRAC expression per se may not underlie changes in Ca2+ signaling in activated and malignant T cells.
Even though multiplicative modulations at preceding stages may underlie these changes, they are effectively nonmultiplicative in nature and do change the selectivity of individual neurons by shifting and sharpening their spatial tuning curves.
Importantly, this was most marked when the combination treatment was compared to the controls suggesting that a common mechanism may underlie those changes.
Indeed, DAT-KO mice display profound alterations in serotonin homeostasis that may underlie the changes in baseline neuron-oscillatory properties presented here [25].
Based on the available literature, decreased repolarization reserve due to downregulation of certain repolarizing potassium currents associated with myocardial hypertrophy may underlie these changes.
Related(20)
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