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Finally, gata3 and PKB/Akt bind directly to smad3 [71], [71] and may thus modulate interactions between IGF and TGFβ-signalling pathways.

A highly sophisticated regulatory network may thus modulate the expression of genes in response to arsenic.

Cardiac mIGF-1/SIRT1 signaling may thus modulate disparate systemic functions.

These immune suppressors may thus modulate HSC immunogenicity and, therefore, contribute to the "immune privilege" of HSCs.

Nevertheless, acute changes in ACh levels may thus modulate this serotoninergic response in a way that does not occur after permanent ACh depletion.

These two candidate genes for T1D may thus modulate β-cell apoptosis and/or local release of inflammatory mediators in the course of a viral infection by acting, at least in part, at the pancreatic β-cell level.

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Although other kinases may also phosphorylate and thus modulate endogenous Atg13, our data strongly suggest that Atg1 is mostly responsible for starvation-induced hyperphosphorylation of Atg13 in Drosophila.

With respect to genetic factors, a number of polymorphisms in various DNA repair genes have been discovered, and it is possible that these polymorphisms may affect DNA repair capacity and thus modulate susceptibility to cancer.

The secretion of these cytokines may, thus, be modulated when fibroblasts are exposed to cigarette smoke.

This association may lead to repression of activated transcription and thus modulate and control transcript levels [ 71, 72].

The ERβ-induced switch may alter this equilibrium, thus modulating such a relevant aspect of cancer biology as p53 stability.

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