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Thus, AhR- and Nrf2-regulated gene expression may represent indirect biomarkers of exposure to DEP.

Glyburide has been shown to prevent neutrophil extravasation and accumulation in animal models [ 19], and this may represent indirect evidence that glyburide was responsible for reducing the incidence of respiratory failure in study patients taking this drug.

It is important to recognize that CD4+ cell loss in the seroconversion period, as well as the nadir CD4+, if in early infection, may represent indirect measures of the intensity of viremia in the initial viral host interaction.

(A list of all SRSF1 translational targets is provided in Supplementary file 1 at Dryad: Maslon et al. (2014).) The SRSF1 translational targets may represent indirect as well as direct events.

This shared genetic risk was not associated with acute stress and may represent indirect evidence of a common etiology involving altered brain dopaminergic activity, consistent with reward deficiency theory [ 2, 5].

Most of the genes that are repressed in exponential phase in the dcl-1Δ/dcl-2Δ and ago-1Δ mutants were also repressed in the rdrp-1Δ mutantsand may represent indirect targets of class II ex-siRNAs (dcl-2, ago-1, rdrp-1-dependent).

Similar(54)

Based on this finding, we speculate that the Tip60 HAT metabolic associated direct and indirect target genes we identified may not only be controlled epigenetically by Tip60 HAT action, but may also represent indirect targets of central metabolic regulator proteins that are directly controlled via their acetylation by Tip60.

A lot of these associations may actually represent indirect interactions [ 17, 18].

The presence of free fluid around the intra-pelvic portion of the round ligaments may represent an indirect sign of endometriosis [11].

Axial contrast-enhanced CT of the lower thorax at mediastinal window shows haemopericardium that may represent an indirect sign of pericardial or heart injury in a polytraumatised patient after a motor vehicle accident.

While in some cases such alterations have little (or no) practical effects, there are situations in which the deviation of contact parameters from the original design is a primary source of malfunctioning and unexpected early failures; thus, the analysis of contact modifications may represent an indirect yet effective method for estimating wear effects.

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