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Numerous human gastrointestinal disorders, such as celiac disease, are also associated with villous atrophy and diarrhea and may represent secondary or acquired forms of sucrase-isomaltase deficiency (Table 1) [21].
These regions may represent secondary sites of interaction for MyD88 and TRIF and interestingly a previous study pointed to the CD loop located on the bottom surface as a binding site for MyD88 [16].
For instance, our small cohort of adult HLH cases may represent secondary HLH.
Alternatively, they may represent secondary interaction to the bait protein that has been stripped from its interactors [ 22].
Alternatively some may represent secondary cancers directly related to the first but which have not been correctly coded as metastases.
Lymphoma occurs infrequently within bone, muscle or skin; this may represent secondary haematologic disease involvement or rarely a primary extranodal site of disease.
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These may possibly represent secondary aberrations that influence the tumor differentiation pattern.
Some aberrations may also represent secondary events that are part of the tumor's genomic signature.
Of note, seven out of the eight adult HLH cases (88%%) were associated with a known trigger of HLH, suggesting that these may truly represent secondary HLH cases.
Nevertheless, further research is needed to investigate the impact of DHRS7 function on these pathways, since these effects were only detected 48 and 72 h following knockdown, but not after 24 h, and may therefore represent secondary effects.
Of note, no major change in metabolic gene pathways was observed in response to TBL1 inhibition (Supplementary Table S1), implying that the metabolic alterations described above (Fig 2C and D) may also represent secondary consequences of alterations in proliferation and/or cell growth.
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