These signals may represent experimental noise, however, given the reproducibility of the signals in comparison to all other treatment groups and the extent to which they are altered (in some cases up to 5-fold) this seems unlikely.
These conditions may represent experimental controls for further studies.
'Failed' primary infections were generally not reported within the original studies and may represent experimental difficulties.
At this stage, a harsh interpretation is that perceived Aβ toxicity may represent experimental artefact rather than the true function of Aβ in vivo during the disease process.
The results from the transplant experiments may represent experimental error or a drastic response of the colonies to novel environmental conditions.
If so, it is possible that most variant forms observed in sequence databases may represent experimental or biological noise, which could be exacerbated by environmental stress or other challenges but even so might not significantly affect phenotype or provide a selective advantage.
