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In conclusion, the test battery framework can identify compounds that disturb processes relevant for human development and therefore may represent developmental toxicants.
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The proliferation of active zones observed in neurexin mutant larvae may therefore represent developmental compensation for reduced muscle excitation.
This suggests that differences in frontal cortex may reflect a developmental delay, whereas differences in temporo-parietal cortex may represent a developmental deviance.
Variations in the degree of incorporation of the vestigial bud may represent the developmental mechanism for the observed phenotypic variation of the UM1, allowing for a variable elongation of its forepart.
These iSMC may represent a developmental phenotype that expands during disease progression [1 5].
Self-reported psychotic experiences in the general population may represent the developmental expression of population genetic risk for psychosis [ 9].
These two studies indicate that neural markers for alcoholism may be present during early adolescence when alcohol or substance use has not been initiated and that these patterns may represent a developmental delay in brain network maturity.
Dentate lesions in a large subset of infants with sudden unexplained death may represent a developmental vulnerability that leads to autonomic/respiratory instability or autonomic seizures, and sleep-related death when the infants are challenged with homeostatic stressors.
Interestingly, we also noted an apparent reduction in SNAP25 expression in wild-type S1BF between 1 and 3 months (Fig. 1B), which may represent ongoing developmental remodelling of synapses in this region.
There is currently no standardized classification for P-proteins although different types were often distinguished by their tubular, fibrillar, granular or crystalline ultrastructure, which may represent different developmental or conformational states of the same protein subunits rather than evolutionarily-distinct families [ 10].
Hypomorphic dcl1 mutants and null hyl1, hst, and hen1 mutants reveal both shared and distinct developmental defects that may represent misexecution of developmental transitions [24].
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