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It is expected that polymorphisms in NER or BER genes may modulate individual susceptibility to PAHs exposure.
A key feature of these molecules is that they do not inhibit overall cellular functioning, although they may modulate individual enzyme activities.
Nevertheless, these findings suggest that other genetic variants highly correlated with rs2046210 at 6q25.1 may be functional and may modulate individual susceptibility to breast cancer.
Liang et al. [ 18] found that CYP1B1 432Val polymorphism may modulate individual susceptibility to lung cancer among smokers in the Chinese population (OR: 2.78, 95%CI: 1.46 5.29).
Taken together, these findings suggest that the variant rs9383935 may modulate individual susceptibility to breast cancer, possibly through regulating miR-27a inhibition of CCDC170 expression.
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Moreover, if these SNPs alter gene expression they may modulate the individual's response to the environment and potentially the risk for particular disease state.
This study suggests that in this Italian population, GSTT1, SULT1A1 and NAT2 polymorphisms may modulate an individual's susceptibility to gastric cancer, particularly when more than one unfavourable genotype is present and in combination with cigarette smoke.
It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk.
Mutations in the IL-27 gene may lead to altered cytokine production and/or activity and thus modulate individual's susceptibility to HVB infection.
Previous genomic studies have identified certain genes belonging to the IFN pathway that are associated with a lack of response to IFN-beta, suggesting that the genetic background of certain individuals may modulate this pathway, and consequently the response to therapy, by specific transcriptional profiles [ 33].
The way individuals appraise positive emotions may modulate affective experience during positive activity scheduling.
Related(20)
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