Sentence examples for may induce senescence from inspiring English sources

If so, the inhibition of SUV39H1 in dividing cells may induce senescence.

Anticancer therapies based on genotoxic stress may induce senescence of cancer cells.

(i) DKC1 knockdown in MEFs may induce senescence or growth impairment that could also explain the reprogramming defect.

Cyr61 inhibits NSCLC cell proliferation by upregulating p53, p21, and p130/Rb gene expression [ 15], suggesting that Cyr61 may induce senescence through a p53-/pRb-dependent pathway [ 36].

First, PIK3CA mutations may interfere with the metastasis process or may induce senescence, which results in a better outcome for patients with mutated tumors.

An alternative hypothesis is that PIK3CA mutations may induce senescence, resulting in a less aggressive phenotype compared with activation of other pathways.

miR-101 may also induce senescence in breast cancer cells by targeting ubiquitin-conjugating enzyme E2N (UBE2N)- and SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 4 (SMandA4) [57] and inhibit the G1-to-S phase transition of cervical cancer cells by targeting FBJ murine osteosarcoma viral oncogene homolog (Fos) [58].

We have demonstrated TLBZT may induce cell senescence in colon carcinoma cells in vitro[ 9], so we further detected cell senescence in CT26 colon carcinoma after three weeks of treatment.

The finding that IGFBP5 promoted survival without inducing proliferation suggests that it may induce cellular senescence.

Our data showed that busulfan treatment significantly increased the number of β-galactosidase-positive cells, suggesting that busulfan may induce the senescence of osteosarcoma cells (Fig. 1d).

The spontaneous regression is thought to take place through a constitutively active DNA-damage response (DDR) pathway, which is a negative regulator of cell cycle progression that may induce cellular senescence (Brodeur, 2003).