Sentence examples for may cause senescence from inspiring English sources

Overexpression of an oncogene such as ras may cause senescence of transformed cells, and this event can be reversed by overexpression of a second oncogene such as c- myc, and Twst1/2 [ 49, 50].

While not triggering proliferation of such 'locked' cells, stimulation with growth factors, hormones and nutrients may cause their senescence.

When the repair mechanisms are unsuccessful, it may cause cellular senescence (permanent cell cycle arrest), oncogenesis, or apoptosis which plays an essential role in survival of the organisms by preventing the multiplication of mutated chromosomes, as well as elimination of indisposed cells, normal embryonic development, and maintenance of cell homeostasis.

This may explain lack of senescence by conventional drugs, which easily cause senescence in cell culture.

These data show that a loss of centrosomal integrity may contribute to the entry of MEFs into senescence in culture, and that centrosomal disruption can cause senescence.

While causing senescence in regular cell density, etoposide failed to cause senescence in contact-inhibited cells.

How can p53 suppress senescence, if it also can cause senescence?

In agreement, p533KR did not cause senescence [ 2].

This predicts that any mutant p53 that cannot cause arrest will not cause senescence too.

As the final stage of leaf development, leaf senescence may cause the decline of photosynthesis and gradual reduction of carbon assimilation, which makes it a possible limiting factor for crop yield.

Restoration of wild-type p53 activity by inhibition of Δ133p53 and the resulting degradation of TRF2 [ 26, 27] may cause telomere uncapping-induced senescence or apoptosis through the TRF2-ATM-p53 positive feedback loop in cancers with wild-type p53.