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Irradiation may induce direct cell killing through DNA double-strand breaks.

Second, hyperuricemia may induce direct renal injury through the activation of the renin-angiotensin aldosterone system (RAS).

Ionizing radiation is an example of a physical genotoxic agent that may induce direct (via energy absorption) or indirect (via high production of reactive free radicals) damage to DNA molecules.

Changes in the structure and productivity of the algal community may induce direct structural changes in the rest of the ecosystem and/or indirectly affect the ecosystem by affecting water quality (Nyholm and Petersen 1997 ).

As the cartilage deteriorates to the point at which it is no longer intact, bone-on-bone interactions can occur, which may induce direct mechanical stimulation of these sensitized nerve fibers that are present in the adjacent bone [ 1, 20].

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Despite its usefulness, X-ray may also induce direct or indirect harmful effects on cellular constituents and deoxyribonucleic acid (DNA) [ 6, 7].

Second, integrin α3β1 may induce some direct signaling for the induction of inflammatory cytokines, but the contribution of integrin α3β1 signaling is minor in comparison to its TLR2-mediated effects.

Indeed, valve replacement may induce more direct surgical trauma than coronary artery bypass graft (CABG) surgery, whereas combined surgery is associated with a more prolonged CPB time.

UVA, however, produces less severe overall levels of DNA damage than UVB and therefore may be even less likely to induce direct DNA damage-dependent changes of methylation patterns.

They may have adverse effects towards the vascular endothelium when produced in excess, since they may increase immobilization of inflammatory mediators at the surface of endothelial cells [101], permeability of capillaries [102], or induce direct damage to endothelial tissues [103].

PV-IgG do not only induce direct signalling effects on cell junctions and the cytoskeleton but also change gene expression patterns, which may also contribute to pemphigus pathogenesis.

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