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Other important targets are the central nervous system, where metal oxide nanoparticles may induce oxidative damage in brain cells at high doses, and the cardiovascular system, where they may disturb the microcirculation.
However, high doses of iron oxide NPs may induce oxidative stress [ 86].
Excess corticosterone may induce oxidative stress.
ERS may induce oxidative stress to impair endothelial function in the development of hypertension.
Numerous in vitro and in vivo studies have shown that carbon nanotubes and/or associated contaminants or catalytic materials that arise during the production process may induce oxidative stress and prominent pulmonary inflammation.
Both hypoxia and hyperoxia may induce oxidative stress, and relative changes in hyperoxia may trigger upregulation of the hypoxia inducible factor (HIF) [33].
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Chronic inflammation may also induce oxidative stress [ 7].
Therefore, high glucose concentration may (i) induce oxidative stress, (ii) modulate the Bcl proteins, and (iii) prevent the activation of the PI 3-kinase/Akt pathway.
Adrenaline may therefore induce oxidative stress via an OxyR-dependent pathway in a manner reversible by the β-adrenergic blocker propranolol and also by the non-enzymatic manganese-based oxidative stress detoxification system.
Moreover, there are a number of drugs (e.g., ketoconazole) used in the pharmacotherapy of skin diseases based on the activation of Nrf2, but they may also induce oxidative stress.
On the other hand, it needs to be remembered that iron may also induce oxidative stress, mainly via involvement in the production of reactive oxygen and nitrogen species, and its pro-oxidative properties potentially may have deleterious effects on renal structure and function.
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