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Infectious processes may induce functional dyspepsia [8].
In sepsis, a number of different mechanisms may induce functional modulation of the endothelium, including increased expression of cell adhesion molecules and trafficking of leukocytes [49].
In addition, repeated and long-term migraine attacks may induce functional and structural plastic changes that may underlie the progression of the disorder [8, 9].
The most likely explanation for the rapid development of ExMV research, which has been followed by an exponential increase in the number of published papers in subsequent years, has been the demonstration that these small cellular membrane fragments transfer RNA species and several other biologically active molecules between cells and thus may induce functional changes in the target cells [13 15].
These phenomena may induce functional deficits in neurons and increase neuronal degeneration and the susceptibility to hypoxia and ischemia.
Earlier studies have shown that estrogen deficiency may induce functional changes in large arteries, but structural changes are more likely to be seen in long-term effects [ 10- 15].
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It would be interesting to set up epigenetic studies to explore in depth the hypothesis that stress may indeed induce functional regulatory changes in the abovementioned candidate genes, which may per se lead to hypercortisolism and to the comorbidity of depression, T2D, and MetS.
However, accumulation of endogenous DNA damage may not induce functional decline of the mainly post-mitotic tissue in adult worms.
84 Diabetic neuropathy may also induce functional and morphological alterations that could result in PEI, as proposed by Hardit et al. Alternatively, an antibody against islet cells can cross-react with acinar cells and disrupt its functions.
These observations are also consistent with the hypothesis that exercise training may initially induce functional arterial adaptation, which is followed by structural adaptations in the arterial wall with continued training [ 84, 85].
Unrecorded neurons, for example, may induce apparent functional connectivity between recorded neurons.
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