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Exact(5)

The mechanisms appear dependent on the molecule's open configuration (traditional linker functionality) and possibly a novel mitochondrial specific role, which may include modulation of mPTP function or calcium sensitivity.

Other observations supported this finding [ 207– 209] and suggested that an important treatment option may include modulation of NO metabolism to prevent HCC pathogenesis and improve patient outcomes [ 207].

Another mechanism of cell therapy includes the ability of transplanted cells to promote endogenous repair, which may include modulation of cardiac-resident stem cells and epicardial progenitor cells by specifically regulating endogenous or stem cell-derived paracrine factors.

Moreover, the link between Phi treatment and PSR, as demonstrated by morphological PSR responses and analysis of Pi starvation gene expression following Phi treatment under Pi sufficient and deficient conditions and in auxin and ABA response mutants, suggested that the mechanism of action of Phi may include modulation of Pi signalling involving auxin.

The mode of action of a given probiotic may include modulation of host microflora [ 19, 20], modifications of the morphology of the intestinal epithelium [ 21], regulation of the host immunity system [ 22], and the concentration of gut SCFAs, such as acetate [ 23].

Similar(54)

Other ways in which Hsp70 may suppress include modulation of death pathways (23).

These health-promoting effects may include the modulation of the intestinal microflora, prevention of rotavirus-induced or antibiotic-associated diarrhea, beneficial effects on gastrointestinal tract inflammation, modulate the mucosal immune responses (Roberfroid et al. 2010; Gourbeyre et al. 2011).

The underlying mechanisms may include epigenetic modulation of major inflammatory pathways, yet the details remain unclear.

The mechanism of action is unclear but may include immune modulation at a cellular level as well as direct antiviral activity.

If the association with either PFAA proves causal, possible physiologic explanations may include immune modulation, specific anti-cancer effects, including anti-proliferative, apoptotic and differentiating effects, and physiological changes related to the chemical properties of these PFAAs.

The potential mechanisms underlying these inverse associations between flavonoids and type 2 diabetes risk may include the modulation of the postprandial glucose levels by reducing the activity of digestive enzymes (e.g., α-amylase and α-glucosidase) (34) and decreasing the active transport of glucose across intestinal brush border membrane, inhibiting sodium GLUT2 (35).

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