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Diabetes mellitus may impair bone healing after dental implant placement.
We tested the hypothesis that HFD-induced obesity may impair bone development through elevated FFA levels by increasing bone marrow adipogenesis at the expense of osteoblast differentiation.
Pathophysiological changes in OA affect periarticular bone, and normal bone metabolism requires vit D. Hence, suboptimal levels of vit D may impair bone metabolism and predispose to OA.
11, 49 Literature data suggest that poor metabolic health associated with obesity may impair bone strength and/or density; therefore, obese subjects with a waist circumference exceeding published cut-points, type 2 diabetes, or insulin resistance may be at higher risk for fragility fractures.
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However, some problems should be avoided if BPs are administrated locally that local high drug concentration and massive bone compaction may impair bone-implant integration [ 26, 27].
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Animal studies have shown that dioxin-like OCs may impair normal bone metabolism and result in increased bone fragility [ 32- 34].
Thus, various kinds of AGEs seem to impair bone matrix production and mineralization of osteoblasts, which may lead to the bone fragility seen in diabetic patients.
The predominant effect of GPRC6A deficiency in bone was to impair bone mineralization.
This allows for longitudinal ('bungee-effect') and transverse ('windshield-wiper-effect') graft motion within the bone tunnel, which in turn may lead to bone tunnel dilation, may impair healing of the graft to the bone tunnel and may complicate revision surgery due to loss of bone material.
Pathological settings of anatomical, biomechanical or inflammatory nature may lead to impaired bone healing.
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