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Red blood cells, the authors write, undergo significant changes during storage, including an increase in abnormally shaped red blood cells that may impair oxygen delivery to tissues.

In fact, hyperoxia may impair oxygen delivery in patients with sepsis [ 46].

From a theoretical point of view, very high flow may induce shear-stress lesions to the capillary wall, promoting further microvascular lesions, and may impair oxygen offloading.

Thickened endothelial cells, reduced capillary blood supply and low total number of capillaries may impair oxygen transport to the muscle fibers in inflammatory myopathies [ 12, 13].

A progressive decrease in 2,3-diphosphoglycerate (DPG) levels may impair oxygen delivery [ 5], and a decreased adenosine triphosphate (ATP) pool reduces Na+-K+-ATPase activity and, possibly, ATP-mediated hypoxic vasodilation.

The observation that smoke exposure during pregnancy causes a direct increase in the vascular resistance of the placenta from the fetal side (Geelhoed et al. 2011; Larsen et al. 2002) suggests that PM exposure may lead to an increased resistance of umbilical placental circulation that may impair oxygen and nutrient exchange across the placenta.

Similar(54)

This may potentially impair oxygen and nutrient delivery following reperfusion to an already susceptible organ.

Consequently, changes in capillary wall morphology or blood viscosity may impair myocardial oxygen extraction by preventing capillary flow homogenization.

Thus, whilst SDHD mutations could impair oxygen sensing, low altitude may serve to reduce the penetrance of these mutations.

Histological changes associated with placental CMV infection include avascular and hydropic villi, fibrinoid deposits and syncytial knotting [ 16], all of which may impair transport of oxygen and nutrition to the developing fetus.

Therapeutic hypothermia below 35°C may impair brain tissue oxygenation through a left-shift of the oxygen dissociation curve, therefore enhancing the affinity of oxygen to hemoglobin, or by decreasing delivery of oxygen to the brain [ 21, 41].

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