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The mechanism by which corticosteroids might induce GI bleeding or perforation has not been fully established, but corticosteroids may impair tissue repair, thus leading to delayed wound healing.
The polymers penetrate the soft tissue to a certain extent and adhesion is achieved through an interpenetrating network that is irremovable and may impair tissue development at the integration site.
In addition, while we have shown that IABP may impair tissue perfusion in hemodynamically recovered patients, we did not observe signs of cell ischemia (for example, lactate acidosis) nor signs of progressive organ dysfunction during IABP-therapy on the day measurements were performed.
The present study however has favored a "scaffold-free" approach over the use of biomaterial scaffolds, which may impair tissue formation due to unpredictable degradation rates and potential adverse immunogenicity of the degradation products therein (van der Kraan et al., 2002).
Similar(56)
Therapeutic hypothermia below 35°C may impair brain tissue oxygenation through a left-shift of the oxygen dissociation curve, therefore enhancing the affinity of oxygen to hemoglobin, or by decreasing delivery of oxygen to the brain [ 21, 41].
If more severe sepsis develops, increasing bits of dead tissue and toxic material then may impair various tissues, if sepsis worsened such that blood flow to vital organs becomes very impaired.[4].
Moreover, large amounts of glue may be impairing tissue ingrowth through the mesh pores, leading to poor tissue integration.
Among several hypotheses, one may consider that large fluid resuscitation can impair tissue oxygenation [ 22].
Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita.
A possible explanation may be related to a deficiency of vasoactive neuropeptides in patients with neuropathy, which may impair normal soft tissue and osseous healing (14).
28 Furthermore, trophic effects of glucocorticoids on connective tissue may impair barrier function and result in long-term changes in host vulnerability to infection, for example skin atrophy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com